Read e-book online Clinical pharmacology of sleep PDF

By S.R. Pandi-Perumal

ISBN-10: 3764372621

ISBN-13: 9783764372620

ISBN-10: 3764374403

ISBN-13: 9783764374402

Covers medical and pharmacological remedies for varied sleep issues, corresponding to insomnia, sleep apnea, narcolepsy, stressed legs syndrome, and periodic limb circulate syndrome. This quantity addresses using sleep medicinal drugs in childrens, youth, and within the aged, and likewise deals an summary of hypnotic medications.

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Kubin L, Tojima H, Davies RO, Pack AI (1992) Serotonergic excitatory drive to hypoglossal motoneurons in the decerebrate cat. Neurosci Lett 139: 243–248 26. Bayliss DA, Viana F, Talley EM, Berger AJ (1997) Neuromodulation of hypoglossal motoneurons: cellular and developmental mechanisms. Respir Physiol 110: 139–150 27. Ribeiro-do-Valle LE, Metzler CW, Jacobs BL (1991) Facilitation of masseter EMG and masseteric (jaw-closure) reflex by serotonin in behaving cats. Brain Res 550: 197–204 28. Douse MA, White DP (1996) Serotonergic effects on hypoglossal neural activity and reflex responses.

The group apnea-hypopnea index (AHI) improved with fluoxetine compared to placebo, but there was great variability of response and other measures of disordered sleep did not change. These potentially beneficial results in a small number of patients need to be replicated in well-designed larger studies to support a useful role in clinical practice. Paroxetine and trazodone Paroxetine is another SSRI that has undergone a trial in a small number of patients with mild to moderate sleep-disordered breathing, and been shown to produce modest decrements of the apnea index in NREM sleep only [53].

Szkudlarek J, Elsborg L (1993) Treatment of severe obesity with a highly selective serotonin re-uptake inhibitor as a supplement to a low calorie diet. Int J Obes Relat Metab Disord 17: 681–683 Neuropharmacology of obstructive sleep apnea and central apnea 39 102. McElroy SL, Hudson JI, Malhotra S, Welge JA, Nelson EB, Keck PE Jr. (2003) Citalopram in the treatment of binge-eating disorder: a placebo-controlled trial. J Clin Psychiatry 64: 807–813 103. Malhotra S, King KH, Welge JA, Brusman-Lovins L, McElroy SL (2002) Venlafaxine treatment of binge-eating disorder associated with obesity: a series of 35 patients.

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Clinical pharmacology of sleep by S.R. Pandi-Perumal

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