By J. F. Snell
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However, in a system composed of L cystine, phenyl acetate, and salts, the addition of L-valine stimu lates the rate of antibiotic production by starved resting cells (Demain, 1956). D-Valine, on the other hand, inhibits penicillin synthesis. The addition of α-methyl-DL-valine is inhibitory to peni cillin formation, and its action can be reversed by L-valine. Penicil lin synthesis by washed resting cells proceeds as well in L-valine plus L-cystine as it does with lactose (Fig. 4 ) . Another inhibitor of 1 80 TIME (HOURS) F I G .
Chaiet, L . , Miller, W . J . , Wolf, F . J . , and Hendlin, D. ( 1 9 6 2 ) . Biochim. Biophys. Acta 6 0 , 4 4 7 . 26 D. PERLMAN Gatenbeck, S. ( 1 9 6 1 ) . Biochem. Biophys. Res. Commun. 6, 4 2 2 . , Pan, S. , and Numerof, P. ( 1 9 5 3 ) . Science 118, 4 3 . , Carter, Η. E . , Robbins, P. W . , and Burg, R. W . ( 1 9 6 2 ) . / . Bacteriol. 84, 8 8 8 . , and Grisebach, U. C. ( 1 9 6 0 a ) . Naturwissen schaften 47, 2 0 6 . , and Hofheinz, W . ( 1 9 6 0 b ) . Z. Naturforsch. 15b, 5 6 0 . Halliday W .
Biosynthesis of Antibiotics by J. F. Snell