Read e-book online Bioinformatics for Geneticists PDF

By Michael R. Barnes

ISBN-10: 0470843934

ISBN-13: 9780470843932

ISBN-10: 0470843942

ISBN-13: 9780470843949

ISBN-10: 3527305416

ISBN-13: 9783527305414

This well timed booklet illustrates the price of bioinformatics, no longer easily as a collection of instruments yet fairly as a technological know-how more and more necessary to navigate and deal with the host of knowledge generated via genomics and the provision of thoroughly sequenced genomes. Bioinformatics can be utilized in any respect phases of genetics learn: to enhance research layout, to aid in candidate gene id, to assist info interpretation and administration and to make clear the molecular pathology of disease-causing mutations. Written in particular for geneticists, this booklet explains the relevance of bioinformatics displaying the way it can be used to reinforce genetic facts mining and markedly enhance genetic research.

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Read e-book online Bioinformatics for Geneticists PDF

This well timed e-book illustrates the worth of bioinformatics, no longer easily as a collection of instruments yet fairly as a technological know-how more and more necessary to navigate and deal with the host of data generated by way of genomics and the provision of thoroughly sequenced genomes. Bioinformatics can be utilized in any respect phases of genetics study: to enhance examine layout, to help in candidate gene identity, to assist facts interpretation and administration and to make clear the molecular pathology of disease-causing mutations.

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1989), Heun et al. (1991), and McCouch et al. (1988). 2 Mapping Populations for Cross-pollinating Species If pure lines cannot be generated from a species due to self-incompatibility or inbreeding depression, heterozygous parental plants are used to derive mapping populations such as F1 and backcross lines (BC). This is the case for several tree species such as apple, pear, and grape and for potato. For the tree species crosses between different cultivars are used to produce F1 progenies to be genotyped (Maliegaard et al.

Such a method is particularly applicable when a large set of mutants needs to be mapped in a limited time. This concept was implemented by Castiglioni et al. (1998), who mapped mutations in barley by an AFLP-based procedure. The procedure takes advantage of the very high diversity index of AFLP markers that allows the screening of a whole genome with a limited number of PCR primer combinations. In the cited work, a genetic map comprising 511 AFLP markers was derived from the cross between the lines Proctor q Nudinka.

2001). In this context, cytogenetic maps based on FISH provide complementary information for the construction of physical maps to position BAC clones (Islam-Faridi et al. 5). 7 Specific Mapping Problems A loss in genetic diversity inevitably causes problems for the breeding of new varieties. The genus Lycopersicon, which comprises modern tomato cultivars, is an example of this development (Miller and Tanksley 1990). 5. Alignment of the genetic and physical map of sorghum chromosome 1 (figure taken from Islam-Faridi et al.

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Bioinformatics for Geneticists by Michael R. Barnes


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