By Professor and Chair Dr Yunbo Li
This can be a e-book that takes a distinct method of integrating wisdom in antioxidants from necessities to advances, and from simple study to scientific functions. This e-book provides medical info on antioxidants in an organised, cogent, and in-depth demeanour. The constant structure of writing, the full-colour illustrations, and the great checklist of references make the publication available and fascinating. along with its price as a textbook for undergraduate and graduate scholars in lifestyles technological know-how, "Antioxidants in Biology and medication" can also be an invaluable reference for biomedical study scientists, clinicians, and different health and wellbeing pros.
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Additional resources for Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications
Oxidation of cysteine residues of Keap1: Keap1 is a cysteine-rich protein, and the cysteine residues may serve as redox sensors for ROS/RNS or chemical inducers. Modifications of these cysteine sulfhydryl groups on Keap1 protein is thought to cause dissociation of Nrf2 from Keap1. Phosphorylation of Nrf2: Several protein kinases, including protein kinase C, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase have been suggested to phosphorylate Nrf2, leading to dissociation of Nrf2 from Keap1.
Sankaranarayanan K, Jaiswal AK. Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. J. Biol. Chem. 2004;279:50810-50817. Yang H, Magilnick N, Lee C, Kalmaz D, Ou X, Chan JY, et al. Nrf1 and Nrf2 regulate 30            Antioxidants in Biology and Medicine rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. Mol. Cell. Biol.
This is also true for the development of antioxidant-based strategies for the intervention of disease conditions involving an ROS/RNS-mediated pathophysiological component. Three approaches as outlined below are commonly used to study antioxidant intervention of diseases in experimental animals. Administration of exogenous antioxidant compounds Transgenic overexpression of antioxidant proteins Induction of endogenous antioxidants by chemoprotective agents Transgenic approach provides the most convincing information regarding the effects of overexpression of a particular antioxidant protein on a disease condition.
Antioxidants in Biology and Medicine: Essentials, Advances, and Clinical Applications by Professor and Chair Dr Yunbo Li