Download e-book for kindle: ABC Transporters and Multidrug Resistance by Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

By Ahcène Boumendjel, Jean Boutonnat, Jacques Robert

A accomplished evaluation of the most up-tp-date clinical study on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are identified to play an important function within the improvement of multidrug resistance (MDR). MDR is the facility of pathologic cells, akin to tumors, to resist chemical substances designed to focus on and break such cells. In MDR, sufferers who're on drugs ultimately increase resistance not to simply the drug they're taking, yet to a number of types of drugs.

ABC Transporters and Multidrug Resistance bargains a vital source for pharmaceutical researchers who're operating to find medicines to counteract multidrug resistance in illnesses akin to melanoma. in a single accomplished quantity, this ebook features a selection of the most up-tp-date wisdom at the involvement of ABC transporters in drug shipping and resistance.

This complete quantity offers an outline at the description of the constitution, the genome, common tissue expression, physiological point, and mechanism of motion of the ABC protein. The specialist members discover the expression, detection, and implications of ABC proteins in hematological malignancies and sturdy tumors and ABC proteins and pathogenic microorganisms. This quantity additionally explains MDR modulation via inhibition of ABC transporters and the layout of inhibitors and mechanism of motion. furthermore, the booklet bargains crucial info at the organic and medical point of multidrug resistance.

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Sample text

The authors showed that increasing differentiation of leukemic cells (induced by RARα overexpression) induced an increase in ABCB1 gene expression in cells from solid tumors. Nevertheless, it did not result in elevation of constitutive P-gp functional activity, but it could participate in the control of P-gp induction. Sulová et al. (110) recently reported that combined treatment of P-gp positive cells with verapamil and ATRA induced a depression of P-gp expression and/or transport function whereas ATRA alone did not.

THE P-GLYCOPROTEIN 170 asymmetric configuration in the nucleotide-bound state. J Biol Chem 280: 2857–2862. Vandevuer S, Van Bambeke F, Tulkens PM, and Prévost M. 2006. Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: Insight into the mechanism of ligand migration and binding sites. Proteins 63: 466–478. Lee JY, Urbatsch IL, Senior AE, and Wilkens S. 2008. Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.

Genetic polymorphisms in MDR1 and CYP3A5 and MDR1 haplotype in mainland Chinese Han, Uygur and Kazakh ethnic groups. J Clin Pharm Ther 32: 89–95. 56. Kimchi-Sarfaty C, Marple AH, Shinar S, Kimchi AM, Scavo D, Roma MI et al. 2007. Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene. Pharmacogenomics 8: 29–39. 57. Crettol S, Venetz JP, Fontana M, Aubert JD, Ansermot N, Fathi M et al. 2008. Influence of ABCB1 genetic polymorphisms on cyclosporine intracellular concentration in transplant recipients.

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ABC Transporters and Multidrug Resistance by Ahcène Boumendjel, Jean Boutonnat, Jacques Robert


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